Acyclovir plus CMV immunoglobulin prophylaxis and early therapy with ganciclovir are effective and safe in CMV high-risk renal transplant pediatric recipients
نویسندگان
چکیده
منابع مشابه
Impact of high-dose oral acyclovir prophylaxis on cytomegalovirus (CMV) disease in CMV high-risk renal transplant recipients.
Recent studies showed contradictory results concerning the efficacy of oral acyclovir in the prevention or amelioration of cytomegalovirus (CMV) disease after renal transplantation (TX). This study evaluated the incidence and severity of CMV disease within the first year after TX in high-risk renal transplant recipients (CMV-seropositive donor, seronegative recipient) treated prophylactically w...
متن کاملAcyclovir/cytomegalovirus immune globulin combination therapy for CMV prophylaxis in high-risk renal allograft recipients.
CYTOMEGALOVIRUS (CMV) remains a common complication after renal transplantation. As previously reported. CMV has a significant impact not only on the clinical outcome after transplantation but also on its cost; for patients with CMV. cost is increased 2.9-fold as a result of extended hospitalization. I The risk of developing CMV disease after renal transplantation is highest in seronegative pat...
متن کاملIncidence of ganciclovir resistance in CMV-positive renal transplant recipients and its association with UL97 gene mutations
Human cytomegalovirus (CMV) remains the most common infection affecting organ transplant recipients. Despite advances in the prophylaxis and acute treatment of CMV, it remains an important pathogen affecting the short- and long-term clinical outcome of solid organ transplant recipient. The emergence of CMV resistance in a patient reduces the clinical efficacy of antiviral therapy, complicates t...
متن کاملIncidence of ganciclovir resistance in CMV-positive renal transplant recipients and its association with UL97 gene mutations
Human cytomegalovirus (CMV) remains the most common infection affecting organ transplant recipients. Despite advances in the prophylaxis and acute treatment of CMV, it remains an important pathogen affecting the short- and long-term clinical outcome of solid organ transplant recipient. The emergence of CMV resistance in a patient reduces the clinical efficacy of antiviral therapy, complicates t...
متن کاملLate CMV Disease and/or Recurrence in Renal Transplants Recipients with Prolonged Oral Ganciclovir Prophylaxis
Background/Aim: Oral ganciclovir effectively prevents CMV disease, but late-onset CMV disease is increasingly observed in pancreas-kidney and bone-marrow transplants recipients, specially with long-term prophylaxis. Then, the aim of this study was to verify if prolonged administration of oral ganciclovir prophylaxis could induce late CMV recurrence or disease in renal transplant recipients Mate...
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ژورنال
عنوان ژورنال: Transplant International
سال: 1998
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.1998.tb01096.x